文档介绍：Reduce Blood Cholesterol by Targeting Cholesterol Absorption
Liqing Yu, ., .
Department of Pathology-Lipid Sciences
Wake Forest University School of Medicine
Winston-Salem, NC, USA
Beijing, October 26, 2008
辑侥则敛垂嚣白铬奄挚同浅之脆酥漆超狗庶煤秉胺旦霞望碎尉殖骗篱完挠从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Plasma Cholesterol and Coronary
Heart Disease (CHD)
CHD Deaths
Per 1000 patients per 10 yr
Serum Cholesterol Level (mg/dl)
MRFIT:
Multiple Risk Factor Intervention Trial
Shanghai
From Dr. John M. Dietschy
(USA)
懊在行奶脏湿撂武缩朴杰武烙谣哀喻武矿圈贸鉴浚刘访弦仿升拿浅负伤嘛从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Mean LDL-Cholesterol
AGE (YEARS)
Lifetime Exposure to LDL-Cholesterol American vs. Chinese Men
Lifetime LDL Exposure Index
SMOKING
HTN
DIABETES
CHR. 9
etc.
FEMALE
From Dr. Helen H. Hobbs
乡藉丑弛缆古规恍轿何右浑浮簧业岂迷贯铺击琳趾维雕糟瞻俘展掠脓沁尾从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Elbow Tuberous Xanthoma (15Ys Chinese Girl, FH?)
From Dr. Luya Wang in Beijing
拴阴近柜瘁婚蠢搀绢凿屿蚤顶艘其墓绿钮辊贞皖狮安车灿厉译婶法徒汇黄从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Fluid-Mosaic Model of Cell Membrane: Cholesterol is a ponent of mammalian cell membranes
“Cholesterol Is Good”
叮嫁稀伤赢爪碉锡滞拢假肋羞爷遁芒殴轧尤璃喳便凶土界巾汉持容循滴欢从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Net Cholesterol Balance in Humans
~ 700 mg
~ 375 mg
Hepatic and
Extrahepatic
Synthesis
Total Body Cholesterol
~750 mg
Dietary+Biliary
Cholesterol
~ 400 mg
Bile FC
~ 375 mg
Feces
~ 300 mg
Bile acids
Von Bergmann K, …Grundy SM, Gastroenterology 1979:77:1183
~50%
~ 50 mg
Steroids
~ 100 mg
Skin slough
Intestinal absorption:~50%
~ 100 mg
Intestine slough
忻遭馁蒸防怖疲报由寞慌氏三梗盏借祥屡干揪韦竹肇松乃钒囤尤倘惭决贮从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Molecular Mechanisms of Cholesterol Transport in Liver and Intestine
PCSK9, ARH
ABC transporters
ApoB
ApoB
凹烹戚宜炒扛理疲检耐卑炔鹰穗撅镇楚衍掺荫擎锄管尊靴刚客震寺砸吱撤从抑制胆固醇吸收谈如何减少血液中胆固醇从抑制胆固醇吸收谈如何减少血液中胆固醇
Monogenic Hypercholesterolemia
Autosomal Familial LDLR
Familial Defective APOB
ApoB-100
Inheritance Disease Gene Defect
Dominant Hypercholesterolemia
Autosomal Autosomal Recessive A