文档介绍：促黄体生成激素释放激素(LHRH)类似物及其制剂的研究进展
杜丽娜,金义光∗
(军事医学科学院放射与辐射医学研究所,北京 100850)
[ 摘要] 目的:对促黄体生成激素释放激素(luteinizing
hormone-releasing hormone,LHRH)类似物及其制剂的研究进行综述。
方法:综合国内外相关文献报道,对 LHRH 类似物的分类、药理作用、
在前列腺癌治疗方面的应用及其制剂的研究进行综述。结果:LHRH
类似物的药理作用较为广泛,其剂型主要为埋植剂和微球,二者相比,
微球制剂具有更大的优势。结论:LHRH 类似物微球制剂必将拥有更
大的应用前景。
[关键词] 促黄体生成激素释放激素;激动剂;拮抗剂;埋植剂;微球
[中图分类号] ; R977 [文献标识码] A [文章编号]
Advances in luteinizing hormone-releasing hormones (LHRH) and
their formulations
Du Li-na, Jin Yi-guang*
(Beijing Institute of Radiation Medicine, Beijing 100850, China)
[Abstract] Objective: This article reviewed the development of LHRH
analogues and their formulations. Methods: This article focused on the
classification, pharmacology, applications in the treatment of prostate
作者简介: 杜丽娜,博士,助理研究员
* 通讯作者: 金义光,博士,副研究员,Tel: (010)66931220; E-mail: jinyg@
cancer of LHRH analogues and their formulations, including implants and
microspheres. Results: LHRH analogues had extensive clinical
applications and the main formulations were implants and microspheres.
Microspheres had much broader advantages over implants. Conclusion:
Microspheres of LHRH analogues could be applied in clinical use much
prehensively.
[Key words] luteinizing hormone-releasing hormone; agonist;
antagonist; implants; microspheres
生殖,是动物和人类赖以世代繁衍的最基本的生物功能,受神经和
体液等多种因素的调节,与机体各系统的功能状态密切相关,其中内
分泌系统功能的完整