文档介绍：Chapter 11 Hormones(2)
Pei Yu
College of Pharmacy
Jinan University
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Hormones
Steroid Estrogen (雌激素) Non-Steroidal Estrogen &
Selective Estrogen Receptor Modulator
Male Hormones &
Protein Anabolic Hormones (蛋白同化激素)
Progestogen Hormone (孕激素)
Steroid Contraceptive agents (避孕药)
Anti-progestogen(孕激素拮抗剂)
Adrenocorticoids (肾上腺皮质激素)
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Male hormones have male activity and protein assimilation (同化) activity.
Some structure pounds which are called protein anabolic hormones(蛋白同化激素)have very weak male activity but strong protein assimilation activity.
Anabolic hormones are drugs derived from the male sex hormone to promote growth or to help the body repair tissues weakened by severe illness or aging, and it subject to abuse to promote muscle mass in athletes.
The purpose to modify male hormones is to acquire new protein anabolic hormones .
Male Hormones and
Protein Anabolic Hormones(蛋白同化激素)
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Anabolic Hormones
Promote protein anabolism(合成代谢)and reduce its catabolism(分解代谢).
Enhance the procedures of protein synthesis from amino acid.
Clinical uses of anabolic hormones are treating sickness asthenia(虚弱), cacotrophia(营养不良)of new-born and aged people, consume diseases, osteoporosis and gastric and duodenal ulcer (胃十二指肠溃疡) etc .
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Side-effect of Anabolic Hormones
Male activity is the main side-effect of anabolic hormones.
Minor change of structure of Testosterone(睾酮)can cause male activity decrease and anabolic activity increase.
For example:
De-methyl on C-19;
Substitution on ring A
Fused rings of ring A
No anabolic hormones without male activity .
A
19
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Common Male Hormones and Anabolic Hormones
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Testosterone Propionate(丙酸睾酮)
Chemical name:
17-Hydroxyandrost-4-en-3-one propionate
17
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Structure of Testosterone Propionate
Testosterone is a natural male hormones. Separated from male cow testis(睾丸) in 1935.
It is △4-3-ketone and 17β-pound, and here it is propionate.
UV absorption.
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Ab