文档介绍：Renin and Angiotensin angiotenogen ↓(+) ← Renin angiotensin I ↓(+) ← ACE angiotensin II ↓ ( Activation of AT1 ) ↓(+) ← amino- ↓ peptidase inactive pepetide fragments The role of RAS on cardiovascular diseases Renal hypertension: PRA↑ and AgII↑ Congestive heart failure: RAS↑ Cardiovascular remodeling: AT1 Angiotensin converting enzyme inhibitors ( ACE inhibitor) 1960s Ferreira venoms of pit vipers bradykinin (-) kininase II
Erdös Kininase II = ACE
Bradykinin & Ang I Mechanism: angiotenogen kininogen ↓(+) ← Renin ↓ angiotensin I bradyKinin ↓(+) ← ACE →(+) ↓ (kininase II) angiotensin II inactive productions ↓ Activation of AT1 Pharmacological effects Effects on cardiovascular system: (1). vasodilation Both A & V . normal : HR & cardiac output heart failure :cardiac output (2). Increasing the blood flow : brain , heart &kidney 2. effects on endothelial cell