文档介绍：Cancer ics
Medical ics
Cancer is a class of diseases caused by loss of cell cycle control.
Cancer
In animals, cell numbers are under exquisite control
Loss of this control leads to proliferation of unwanted cells
Cancer arises when the above situation reaches a certain degree
Cancer & Tumor
Cancer cells are malignant tumor (vs. benign tumor) cells
All cancer cells are eventually capable of metastasis
Cancer Family
Unusually large numbers of blood relatives develop certain kinds of cancers.
Lynch Cancer Family Syndrome Ⅱ
“Family G”: Italian family
Warthin AS. Heredity with reference to carcinoma. Arch. Intern. Med. 1913. 12: 546-555
Hauser IJ, Weller C. VA further report on the cancer family of Warthin. Am. J. Cancer. 1936.
27: 434-449
Lynch HT, Krush AJ. Cancer family 'G' revisited: 1895-1970. Cancer. 1971. 27: 1505-1511
Lynch Cancer Family Syndrome Ⅱ
“Family G”: Italian family
MIM 114400
Lynch Cancer Family Syndrome Ⅱ
: 18q11-q12
Adenocarcinomas of the colon
“Family G”: Italian family
Carcinoma of endometrium
Gastric cancer, ovary cancer, breast cancer
Li-Fraumeni Syndrome
Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer. (MIM 151623)
Breast tumors
a, leukemia, lung cancer, and adrenal cortical carcinoma
Cancer Family
Earlier age of onset
Multiple close relatives affected
Multiple primary tumours/bilateral disease
Multiple tumours in specific cancer syndrome
Inherited Cancer
Retinoblastoma, RB (MIM 180200)
Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance.