文档介绍：血瘀证与活血化瘀研究进展(上)
江西省中西医结合学会活血化瘀专业委员会
江西医学院第一附属医院李国贤
江西省人民医院王青
第二届中日韩血瘀证及活血化瘀研究学术大会
大会名誉主席: 陈可冀
大会主席: 史载祥石井裕正金聖勳
学术委员会: 杜冠华末松诚申铉守 Frank J. Burczynski
中国江西省中西医结合学会 活血化瘀专业委员会网站
高级顾问: 史载祥石井裕正金聖勳杜冠华
名誉主任委员: 徐炽度曾庆骅
主任委员: 李国贤
副主任委员: 谢建祥赵孟华曹正柳刘中勇张庭
常务编委兼秘书: 吴锐
网址:
从气体生物学看待微循环
末松诚
日本,庆应大学医学院,生物化学与综合医学生物学系
人体所消耗的大部分氧气是作为细胞C氧化酶的底物以维持氧化磷酸化生成ATP,剩余的氧气被用来氧化生物合成,包括血管活性物质的合成,如前列腺素和作为二级气体型活性物如一氧化氮以及一氧化碳。从而,氧气不仅用于维持能量的供应,而且还用于调节组织的血流供应。二氧化碳主要产生于经过三羧酸循环过程的葡萄糖氧化,并且它是强力的血管扩张剂;经过半胱氨酸降解而合成的硫化氢已经被假定为神经调节剂,尽管接受信号的受体蛋白还没有被证实是可辨认的分子实体。有力的穿透力使这些气体轻松的接触内部受体,在微血管受体上执行他们的特殊生物功能。这篇文章主要介绍CO对不同受体蛋白的多样的生物学效应,这些受体包括血管平滑肌细胞的鸟苷酸环化酶,肝细胞的"胱硫醚合成酶, 红细胞的血红蛋白;概述新近的有关生物系统内气体的生成和结合部位的机理的研究资料。
A Microvascular View Gas Biology
Makoto Suematsu
Department of Biochemistry and Integrative Medical Biology,School of Medicine
Keio University,Tokyo 160-8582,Japan
The majority of molecular Oxygen(O2) consumed in tbe body is used as a substrate of cytochrome coxidase to maintain oxidative phosphorylation for ATP Of the O2 used for oxidative biosynthesis including synthesis of vasoactive substances such as prostaglandins and secondary gaseous tediators such as nitricoxide(NO) and carbonmonoxide(CO).Thus,O2 is not only used for maintenance Of energy supply but also for regulating blood supply into dioxide(C02) is generated mainly trough the Krebs cycle as a result of g1ucose oxidation and serves as potent vasodilator,and hydrogen sulfide (H2S) synthesized through dagradation Of cysteine has recently been postulated to be a neuromodulator,although their receptor proteins for sigualing have not been verified as adiscemible molecular ration a11ow these gases to access the inner space of receptor proteins and to execute their specific biological actions on microvascular receptor lecture attempts to focus on diverse biological effects of CO on receptor proteins includings soluble guanylate cyclase in vascular smooth muscle cells,cystadllornine beta synthase in hep