文档介绍：The Cells of the Immune System
Charlie McSharry
Aims and Objectives
By the end of the lectures and lab you should be able to:
appreciate the origin of the cells of the immune system from the bone marrow
describe in simple terms the microscopic appearance of the cells of the immune system:
B and T lymphocytes
plasma cells
macrophages
dendritic cells
describe in simple terms other effector cells such as:
neutrophil, eosinophil and mast cells [polymorphs]
platelets
stromal cells
Morphology and staining characteristics of various types of blood cells. Red blood cells and platelets, which both lack nuclei, are the most numerous. Most numerous of the leukocyte populations are the neutrophils. Lymphocytes are the predominant cell type responsible for immune responses.
erythrocytes and platelets
Platelets and clotting
Granulocytes or Polymorphonuclear (PMN) Leukocytes
A group of white blood cells is collectively referred to as granulocytes or polymorphonuclear leukocytes (PMNs). Granulocytes posed of three cell types identified as neutrophils, eosinophils and basophils, based on their staining characteristics with certain dyes. These cells are predominantly important in the removal of bacteria and parasites from the body. They engulf these foreign bodies and degrade them using their powerful enzymes.
neutrophil
Polymorphonuclear leucocyte - NEUTROPHIL
multi-lobed nucleus.
50-70% of circulating WBC (higher numbers suggestive of bacterial infection).
The fine granules stain poorly with acidic and basic dyes neutrophil.
Primary granules electron dense - contain bactericidal enzymes
Lysozyme, myeloperoxidase; neutral proteases (. elastase); and acid hydrolases (B-glucoronidase
Secondary granules – smaller, not electron dense.
lysozyme, collagenase and lactoferrin and cathepsin B).
Phagocytosis and killing of ingested anisms.
The phagosome fuses with granules to destroy internalized bacteria, oxygen dependent respiratory burst.
DO NOT function a