文档介绍：Interesting facts plement
Are there any?
Secondary immune response
Cobra venom factor
CVF C3 convertase
complement and immuno-pathology 28th Oct 2005
/Acad/
/plement-ecn
plement
classical name: heat-ponent of plasma which ‘complements’ antibody opsonisation and killing of bacteria
plasma proteins most of which circulate as inactive zymogens and are activated at sites of inflammation initiating an enzyme cascade
Define immuno-pathology
contribution of plement system to disease in plement is inappropriately activated, inhibited or deficient
Simple view
C3
Conserved molecule – in echinoderms (ancient 700M years), long before Ig.
The most versatile and multifunctional molecule described to date
Can interact specifically with at least 25 different molecules
C3 central molecule of plement system
Promotes phagocytosis
Supports local inflammatory reactions against pathogens
Instructs the adaptive immune response
Unregulated activation causes tissue damage
Used by pathogens for immune evasion