文档介绍：UNDERSTANDING STEM CELL RESEARCH
Larry Goldstein, .
Vice Chair, Public mittee
The American Society for Cell Biology
UNDERSTANDING THE DEBATE ABOUT HUMAN STEM CELL RESEARCH
WHY ARE THESE TECHNOLOGIES NEEDED?
LIMITS AN TRANSPLANT
“REGENERATIVE MEDICINE”
EMBRYONIC AND ADULT STEM CELLS
SOMATIC CELL NUCLEAR TRANSPLANTATION AND CLONING
SCIENCE
LEGAL SITUATION
CELLS ARE THE FUNCTIONAL UNIT OF THE HUMAN BODY
SMALL BUSINESSES
CELLS HAVE DIFFERENT JOBS
SPECIALIZE/DIFFERENTIATED
PANCREATIC CELLS-INSULIN
NEURONS-TRANSMIT SIGNALS
HEART CELLS-CONTRACT TO PUMP BLOOD
MANY DISEASES ARE CAUSED BY BREAKDOWNS IN THE CELL
SOMETIMES CELL ALIVE BUT DAMAGED
SOMETIMES CELL DIES AND IS LOST
BASIC PRINCIPLES
MANY DISEASES ARE ASSOCIATED WITH TISSUE DAMAGE OR LOSS
ALZHEIMER’S DISEASE-BRAIN CELLS (4 MILLION)
PARKINSON’S DISEASE-BRAIN CELLS ( MILLION)
RETINITIS PIGMENTOSA-RETINAL CELLS
CANCER-VARIOUS ( MILLION)
DIABETES-PANCREATIC CELLS (16 MILLION)
MUSCULAR DYSTROPHY-MUSCLE
HEART FAILURE AND OTHER CARDIOVASCULAR DISEASE-HEART MUSCLE (58 MILLION)
KIDNEY AND LIVER DISEASE
SCIENCE 287:1423
USING ANS TO REPLACE DAMAGED TISSUE
THE GOOD:
KNOWN SOURCES-LIVE DONOR OR CADAVER
SURGICAL REPLACEMENT METHODS ADVANCED
AN ARCHITECTURE GENERALLY APPROPRIATE
THE BAD:
DIFFICULT TO FIND ICALLY MATCHED DONORS
LONGEVITY AND SAFETY CAN BE PROBLEMATIC
THE UGLY
DONOR TISSUE NOT ALWAYS KNOWN, ., ALZHEIMERS OR PARKINSONS
NEED FAR OUTSTRIPS SUPPLY
HOW MIGHT STEM CELLS HELP?
HOW CAN STEM CELLS HELP?
WHAT ARE STEM CELLS?
CELLS THAT CAN DIVIDE TO GIVE RISE TO:
MORE STEM CELLS
CELLS THAT CAN ADOPT SPECIALIZED JOBS
WHY ARE STEM CELLS PROMISING?
THE RAW MATERIAL TO REPLACED DAMAGED CELLS ANS?
TOOLS TO UNDERSTAND BAT DISEASE
LIMITS AN TRANSPLANT
SOLUTION TO SUPPLY AND SOURCE PROBLEMS
OVERVIEW OF NORMAL MAMMALIAN DEVELOPMENT
ADAPTED FROM S/STEMCELL/
SPERM
ZYGOTE
(TOTIPOTENT)
BLASTOCYST
FETUS
FERTILIZATION
INNER
CELL MASS
(PLURIPOTENT)
IMPLANTATION
EGG
(OOCYTE)
ADULT
EXAMPLES O