文档介绍：Lung cancer
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Definition
Background
Malignant neoplasm
arising from
bronchial epithelium
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Historical note
100 years ago 200 cases reported
1895 Roentgen diagnosis possible
1904 Sauerbruch negative-pressure cabin
1912 Davies first lung lobectomy
1941 Zhang Jizheng pneumonectomy
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Epidemiology
Morbidity
19th century rare disease
Before 1950s be rising
Recent 50 years increased sharply
leading cause of cancer death
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Etiology
Occupational exposure
Lung cancer
Air pollution
Lung infection
ic factors
Smoking
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Dominant
Tumor suppressor
K-ras
p53
Myc family
3p
c-jun
rb
Growth factor
Protein tyrosine phosphatase-γ
TGF-α
nm23
EGFR
C-erbB2
Oncogenes and Tumor suppressor genes
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Pathology
Lung carcinogenesis
Anatomic location
Histological classification
Invasion and Metastasis
TNM staging
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Lung carcinogenesis
columnar epithelium
squamous metaplasia
carcinoma in situ
metastatic carcinoma
infiltrating carcinoma
Injury
Risk factors
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Anatomic location
Right
Central
Peripheral
Left
Upper
Middle
lower
Upper
lower
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Classification
Percentage
NSC
75%
Adenocarcinoma
35%
Squamous cell carcinoma
30%
Large Cell carcinoma
10%
SCC
20%
Carcinoids
4%
Rare
1%
Histological classification of lung cancer
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