文档介绍：Part VIII Virus persistent infection
Section I Type of infection
Section II The mechanism of persistent infection
persistent infection
latent infection
chronic infection
slow virus infection
Section II Example of persistent infection
I . Hepatitis B virus, HBV
乙型肝炎病毒
1. Biological properties
a member of the hepadnavirus family
a circular, partially double-stranded DNA, a primer protein, and a viral-specific DNA polymerase associated with the DNA.
complex virion virion,also called the dane particle,is 42nm in diameter.
stable at -20℃ and sensitive to higher temperature(100 ℃ for 1 minute)
HBV anization
two uneven strands of DNA:
(-)sense strand: -
(+)sense strand: -
Baruch Blumberg, 1963: ‘Australian antigen - Au'.
1967: Au was a viral antigen = HBsAg (surface antigen)
Dane, 1970:
Discovered 42nm 'Dane particles‘
HBcAg (core antigen).
1973: HBeAg discovered (endogenous antigen = a truncated version of HBcAg).
secreted filament
secreted sphere
hepatitis B virion
2. The HBV life cycle