文档介绍：GDP方案治疗复发或难治性非霍奇金淋巴瘤的效果观察
新疆医科大学附属肿瘤医院内三科,新疆乌鲁木齐 830011
[摘要] 目的探讨吉西他滨联合顺铂和地塞米松(GDP)方案治疗复发或难治性非霍奇金淋巴瘤(NHL)的效果和不良反应。方法回顾性分析新疆医科大学附属肿瘤医院2008年6月~2010年6月收治的37例复发或难治性NHL患者的临床资料,其中复发者24例,难治者13例。所有患者采用GDP方案治疗,第1、8天给予吉西他滨1000 mg/m2,第1~3天给予顺铂25 mg/m2,第1~4天给予地塞米松40 mg联合化疗,每21天为1个化疗周期。2~6个化疗周期后观察其疗效及不良反应情况。结果经过2~6个化疗周期后,%(20/37),%(7/37),%,%,两组有效率比较差异无统计学意义(P > )。化疗后不良反应主要是骨髓抑制(Ⅲ~Ⅳ%,%)和消化道反应(Ⅲ~Ⅳ%),脱发、肝功能损伤及末梢神经炎不良反应轻,对症治疗后均有缓解。结论 GDP方案对部分复发或难治性NHL的解救有一定疗效,适宜临床应用。
[关键词] 非霍奇金淋巴瘤;复发;难治;药物疗法;联合
[中图分类号] [文献标识码] A [文章编号] 1673-7210(2013)11(b)-0086-03
Observation on efficacy of GDP regimen on relapsed or refractory non-Hodgkin lymphoma
GUO Li HU Xin YANG Shun'e
The Third Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China
[Abstract] Objective To explore the effect and adverse reactions on the therapy of relapsed or refractory non-Hodgkin lymphoma (NHL) by Gemcitabine plus Cisplatin and Dexamethasone (GDP). Methods A retrospective analysis was made on 37 cases of patients with relapsed or refractory NHL in the Tumor Hospital Affiliated to Xinjiang Medical University from June 2008 to June 2010. It included 24 cases of relapsed patients and 13 cases of refractory patients. All patients us