文档介绍：
雄激素阻断治疗增加前列腺癌组织中前列
腺肿瘤干细胞比例#
陈伟,王国民,鲁继东,徐磊,谢冲*
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(复旦大学中山医院泌尿外科,上海 200032)
摘要:目的:研究雄激素素阻断治疗(ADT)对前列腺癌组织中肿瘤干细胞比例的影响。探
讨激素非依赖性前列腺癌形成的机制。方法:应用免疫荧光技术比较接受雄激素阻断治疗和
未接受该治疗的前列腺癌患者术前术后标本中肿瘤干细胞的比例变化。结果:接受雄激素阻
断治疗 3 个月后, 前列腺癌肿瘤干细胞比例明显升高。结论:雄激素非依赖性前列腺癌的
形成可能与前列腺癌肿瘤干细胞有关。
关键词:肿瘤干细胞;雄激素非依赖性前列腺癌;雄激素阻断治疗
中图分类号:
Androgen deprivation therapy can increase the proportion
of prostate cancer stem cells
Chen Wei, Wang Guomin, Lu Jidong, Xu Lei, Xie Chong
(Urology department,Zhongshan Hospital Of Fudan University, ShangHai 200032)
Abstract: objective: to study the effect of androgen deprivation therapy on prostate cancer stem
cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen
independent prostate cancer. Methods: the proportion of cancer stem cells in preoperative and
postoperative prostate cancer tissues pared with immunofluorescence. Results: the
proportion of prostate cancer stem cells was increased with 3 months of androgen deprivation
therapy. Conclusions: the formation of androgen independent prostate cancer may related to
prostate cancer stem cells.
Keywords: cancer stem cells; androgen independent prostate cancer; androgen deprivation therapy
0 引言
前列腺癌是男性最常见的肿瘤之一,在过去的几十年里,雄激素被看做是前列腺癌的重
要促进因子,甚至是前列腺癌的病因之一。因此,雄激素阻断治疗(Androgen deprivation
therapy, ADT)成为前列腺癌的常规治疗[1,2]。然而,大多数前列腺癌在 ADT 后变为雄激素
非依赖性