文档介绍：Electrodeposition of chitosan/gelatin coating on titanium: physicochemical characteristics, cell attachment and proliferation
Postgraduate:Zhang Zhen
Supervisor:Prof. Wang Yining
Introduction
Titanium implant is widely used in dental/craniofacial implants.
It is only passively integrated with bone and lack interaction with the surround tissue.
severe bone loss
restoration after
tumor excision
Titanium surface modification to enhance bone growth and Inhibit tumor growth
Approaches of modification of the implant surface can be classified as physicochemical, morphologic, or biochemical.
Chitosan can be used as a bioactive coating and mediate assembly of ponents.
Chitosan
drug carriers
gene delivery
tissue engineering
bioactive coating
extended to the base
and sidewalls of
microfluidic channels
implant
Traditional methods to deposit chitosan on titanium have drawbacks respectively.
Chitosan can be electrodeposited at a Aurum surface
It prompt us to deposit chitosan on titanium surface by electrodeposition.
Advantage
Electrodepositing chitosan
Various ship
NO couplant
No acid remain
simple
controlled
Low temperature
According to our experiment result, cell attachment and proliferation were not good on chitosan
Gelatin is blended with
chitosan to improve the biological activity
.
Chitoan
Gelatin
Chitosan
gelatin
Gelatin can enhance cell attachment and proliferation
Objectives