浅析血清中AFP, AFU, γ-GT 联合检测的临床意义.doc

文档介绍：浅析血清中AFP,AFU,γ-GT联合检测的临床意义
Significance bined Detection of AFP,AFU,and γ-GT in the Serum of Liver Cancer Patients
姚涛
YAO Tao
长沙市传染病医院检验科(中国 410011)
Chang Sha City Hospital For Infectious Disease
中图分类号:+2 文献标识码:A 文章编号:1818-0086(2009)03
摘要:目的研究3种血清检测指标对原发性肝癌诊断的临床意义,以提高对原发性肝癌检测的敏感性。方法取原发性肝癌患者50例,肝硬化患者50例, 其它恶性肿瘤患者50例, 健康志愿者60例血清,应用放射免疫法(RIA)检测AFP(甲胎蛋白),速率法检测AFU(a-l岩藻糖甘酶),γ-GT(谷胺酰转肽酶)。结果原发性肝癌各项指标与其它恶性肿瘤组,肝硬化组比较三项都有明显差异。原发性肝癌组单项AFP,AFU,γ-GT阳性检出率分别是74%,64%,68%。AFP,AFU,γ-GT诊断符合率分别是81%,84%,79%。联合检测敏感性达96%,与单项AFP(74%)检测敏感性有显著差异(P〈)。结论联合测定AFP,AFU,γ-GT可提高对原发性肝癌的阳性诊断率。
关键词: 甲胎蛋白;原发性肝癌;肿瘤标志物
Abstract: Objective The clinical significance of the diagnosis of primary hepatic cancer through the detection results of there kinds of serum was studied,and the sensitivity in primary hepatic cancer was improved. Methods AFP,AFU and γ-GT in the serum of liver cancer patients(50),cirrhosis patients(50),malignant thumor patients(50) and healthy volunteers(60) were determihated respectively by RIA and rate were obvious difference of AFP,AFU and γ-GT between the primary hepatic cancer patients group and cirrhosis patients group,malignant tumor patients groups. Results The positive detection rate of AFP, AFU and γ-GT were respectively 74%,64% and 68% in primary hepatic cancer patients group. The rate of definitive diagnosis were respectively 81%,84% and 79%. There was obvi