文档介绍：现代生物医学进展 gress in Modern Biomedicine ·3757 ·
阿司匹林抑制动脉粥样硬化作用机制的研究进展
邱满堂 1 吴晓燕 2 戚晓红 2△
(1 南京医科大学第一临床医学院江苏南京 211166;2 南京医科大学机能实验学教研室江苏南京 211100)
摘要:目前,临床上常使用阿司匹林进行心血管疾病的一、二级预防。阿司匹林可以非特异性地抑制环氧合酶,进而发挥抗动脉粥
样硬化的作用。大量研究表明阿司匹林还可以通过非环氧合酶途径如抗氧化、调节血管舒缩、对炎症因子的转录调控等来发挥预
防作用。本文就近年来阿司匹林抑制动脉粥样硬化作用机制方面的研究予以综述。
关键词:动脉粥样硬化;阿司匹林;环氧合酶;非环氧合酶途径
中图分类号: 文献标识码:A 文章编号:1673-6273(2010)19-3757-03
Progress on the mechanism of aspirin's anti-atherosclerotic effects
QIU Man-tang, WU Xiao-yan, QI Xiao-hong
(The First Clinical Medicine College of Nanjing Medical University Nanjing China 21116)
ABSTRACT: Atherosclerosis is the base of many cardiovascular diseases and aspirin has been widely used for the primary and sec-
ondary prevention of cardiovascular diseases, because it is proved that aspirin can reduce atherosclerosis. Pharmacologically, aspirin
inhibits cyclooxygenase nonspecifically which inhibits inflammation at the same time, but the inhibition of inflammation cannot account
for all. In recent years, many researchers have noticed that aspirin had a cyclooxygenase-independent way to attenuate atherosclerosis,
anti-oxidation, regulating the systolic and diastolic ability of vessels by affecting NO release, and regulating the transcription of inflam-
matory cytokines are involved. This review focuses on recent researches on the mechanism of asp