文档介绍：an Dysfunction Syndrome
Pathophysiology Department, Tongji
Medical College, HUST
World War One
Circulatory failure, hypovolemic shock
World War Two
Korean War
Post-traumatic acute renal insufficiency
Viet Nam War
Post-traumatic acute respiratory insufficiency
Seventy’s
70’s syndrome
1991
an dysfunction syndrome
Left leg open trauma
Day 2:
Shortness of breath, Oliguria
Day 4:
T ℃↑WBC (18×109/L) ↑
R 35 /m, cyanosis, PaO2<60mmHg
Urine <100ml/d
Creatinine ↑↑ BUN ↑↑
Renal failure
Respiratory failure
Day 6:
Death
Case report
an Dysfunction Syndrome (MODS) is dysfunction of two or ans (initially uninvolved developing within a short period of time.
short period
two or ans
initially
Definition
uninvolved
Cor pulmonale?
Multiple an failure.
The role of uncontrolled infection .
They studied multiple parameters in
553 consecutive emergency surgical
patients.
MSOF is primarily due to infection.
MSOF is the mon fatal
expression of uncontrolled infection.
1980,115(2):136-140.
Causes
Why did anti-biotic strategies
fail in some
of the patients with MODS?
MODS
Biliary tract infection
Shock
Pancreatitis
Burn
Intra-abdominal infection
Infective diseases
Non-infective diseases
Multiple trauma
Bacterial translocation
The viable bacili ote from the gastrointestinal tract to the ans.
Intestinal flora imbalance
Intestinal mucosal ischemia
Immune dysfunction
Causes for the translocation