文档介绍：·68 · 传染病信息 2012 年 4 月 30 日第 25 卷第 2 期 Infect Dis Info, Vol. 25, No. 2, April 30, 2012
IL-28B 基因多态性与丙型肝炎关系的研究进展
孙亚朦,尤红
[摘要] 白细胞介素(interleukin, IL)-28B 即干扰素λ3,是一类属于干扰素λ家族的新型 IL,编码基因位于 19 号染色体
上。 IL-28B 基因的单核苷酸多态性与基因 1 型 HCV 感染者自发清除以及聚乙二醇干扰素α和利巴韦林联合治疗抗病毒
应答率之间的关系已有大量研究报道。然而,随着直接抗病毒药物的应用,IL-28B 基因型对于三联疗法应答率的预测作用有
待进一步研究。此外,IL-28B 对基因 2、3 型 HCV 感染者抗病毒治疗应答率的影响尚不确定,对肝纤维化进展的影响也存
在争议。本文就以上几方面的最新进展进行综述。
[关键词] 白细胞介素-28B;多态现象,单核苷酸;丙型肝炎病毒
[中国图书资料分类号] ; [文献标志码] A [文章编号] 1007-8134(2012)02-0068-03
Research progress of association between
IL-28B gene polymorphisms and hepatitis C
SUN Ya-meng, YOU Hong
Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
[Abstract] Interleukin (IL)-28B gene, interferon-lambda 3 (IFN-λ3), a new member of the interferon family, is encoded and
located on the chromosome 19. An association between single nucleotide polymorphisms of the IL-28B gene and HCV-1 clearance,
and spontaneous recovery or sustained virological response in pegylated interferon and bination therapy have been ex-
tensively described. With the application of direct-acting antiviral agents, it is necessary to determine the role of IL-28B genotype
in predicting SVR in HCV patients receiving triple therapy regimens. In addition, the effect of IL-28B gene on virological response
of antiviral therapy fo