文档介绍：2011 39 4
天津医药年 4 月第卷第期 315
doi:.0253-
尼莫地平治疗创伤性蛛网膜下腔出血的临床研究
王毅张建宁△
92
摘要目的:评价创伤性蛛网膜下腔出血早期应用防治脑血管痉挛药物尼莫地平治疗的临床效果。方法:将
46
例创伤性蛛网膜下腔出血患者随机分为对照组和治疗组,每组例。对照组采用脱水降颅内压、营养神经等治疗;治
14 d 7 d
疗组在对照组基础上于入院后立即给予尼莫地平注射液静脉泵入,疗程后改为尼莫地平片口服,疗程;开颅
GCS
手术患者于术中以尼莫地平稀释液灌洗手术野。记录伤后格拉斯哥昏迷评分( )变化,监测颅内压,应用经颅多普
TCD MCA Vp 3 GOS
勒( )检测伤侧大脑中动脉( )收缩峰流速( )变化,伤后个月随访记录格拉斯哥预后评分( )。结果:
CVS % % χ= < 2
治疗组脑血管痉挛( )发生率( )低于对照组( ),差异有统计学意义( 2 ,P ), 组不同时
Vp GCS < 3 % %
间的值、和颅内压差异有统计学意义(P ), 个月后治疗组预后不良率( )低于对照组( ),
χ= <
差异有统计学意义( 2 ,P )。结论:在颅脑创伤早期使用尼莫地平治疗创伤性蛛网膜下腔出血可以减少
CVS
的发生。
, ,
关键词尼莫地平蛛网膜下腔出血创伤性血管痉挛颅内格拉斯哥昏迷量表大脑中动脉颅内压
Clinical Study of Therapeutic Effect of Nimodipine on Traumatic Subarachnoid Hemorrhage
WANG Yi , ZHANG Jianning
Tianjin Medical University, Tianjin 300070, China
To observe the early therapeutic effect of nimodipine on cranio-cerebral trauma with subarach⁃
Abstract Objective:
noid hemorrhage (SAH). y-two patients with cerebral plicated by SAH were randomly divided into
Methods:
two groups ( =46 for each group). Patients in treatment group were injected nimodipine intravenously by micro-pump for 14
n
days, and then oral administration for 7 days. Patients in control group were received the same treatment measures but without
nimodipine. The values of intracra