阿德福韦酯及恩替卡韦治疗慢性乙型肝炎2 年临床随机对照研究.pdf

文档介绍：中国药物与临床年月第卷第期,
2011 3 11 3 Chinese Remedies & Clinics March 2011,, ·259 ·
阿德福韦酯及恩替卡韦治疗慢性乙型肝炎
年临床随机对照研究
2
王艳王荣荣赵龙凤任娇龙
摘要目的比较阿德福韦酯( )与恩替卡韦对慢性乙型肝炎( )的抗病毒作用,并探讨乙型肝
【】 ADV CHB
炎病毒抗原( )生化水平等对核苷类抗病毒药物作用的影响方法收集年月至年月我
e HBeAg 、。 2007 3 2008 8
院门诊患者例,随机分为组,抗病毒治疗年采用多因素重复测量方差分析结果种药物对乙型
CHB 85 2 2 。。 2
肝炎病毒( ) 的抑制作用比较差异有统计学意义( ); ( )之间抗病毒效果比较差异有统
HBV DNA P= HBeAg +/-
计学意义( );丙氨酸转氨酶( )分组比较,差异无统计学意义( ) 结论恩替卡韦抗病毒快速
P< ALT P= 。①
平稳,优于; ( )组患者均出现明显的病毒抑制, 年时阴性组水平低于阳性组;
ADV ②HBeAg +/- 2 HBV DNA ③ALT
水平不影响核苷类似物的抗病毒作用
。
肝炎,乙型,慢性;生物医学研究; 阿德福韦酯; 恩替卡韦
【关键词】
Efficacy of adefovir dipivoxil and entecavir in chronic hepatitis B: a 2 -year randomized controlled study
WANG Yan, Wang Rong-rong, ZHAO Long-feng, Ren Jiao-long. Department of Infective Disease, the First Hospital
of Shanxi Medical University, Taiyuan 030001, China
【Abstract】 Objective pare the anti-viral effects of adefovir dipivoxil (ADV) and entecavir (ETV) in
chronic hepatitis B (CHB), and to study the impact of HBeAg and patient biochemistry on anti-viral effects of nucleo-
side agents. Methods Eighty-five CHB patients registered to our hospital clinics between March 2007 to August
2008 were randomly divided into two groups and underwent antiviral therapy for two years. Results Significant differ-
ence in HBV DNA inhibition by ADV and ETV was noted (P=). Th