文档介绍：:..程序性死亡配体-1(PD-L1)表达调控在肿瘤中的研宄进展冯如雪孙国平(通信作者)(安徽医科大学第一附属医院肿瘤内科安徽合肥230022)【摘要】免疫逃逸近期被认为是肿瘤进展的重要角色。程序性死亡配体-l(Programmeddeathligand-1,PD-L1)是近年发现的只•有负性免疫调节作用的B7家族的成员,PD-L1与表达于T淋巴细胞表面的受体程序性死亡受体-1(Programmeddeath1,PD-1)-L1被发现在多种肿瘤细胞中高表达并与预后负相关。抗PD-L1/PD-1抗体应用于肿瘤的治疗并带来显著效果。但只有部分患者治疗有效。因此,进一步了解PD-L1表达调控将有利于抗PD-L1/PD-1抗体治疗的改进。木文就PD-L1表达调控的研究进展进行总结概括。【关键词】程序性死亡配体-1;表达调控;肿瘤【中图分类号】R73 【文献标识码】A【文章编号】2095-1752(2016)21-0017-02Researchprogressintheregulationofprogrammeddeathligand-1(PD-L1)expressionintumorFengRuxue,SunGuoping(correspondingauthor).TheFirstAffiliatedHospitalofMedicalUniversityOfAnhui,AnhuiProvince,Hefei230022,China【Abstract】Therecentimmuneescapeisconsideredtobeanimportantroleintumorprogression,programmeddeathligand-1(PD-L1)isamemberoftherecentlydiscoveredhasanegativeregulatoryroleofimmuneB7family,andtheexpressionofPD-L1receptorinprocessTlymphocytedeathreceptor-1(PD-1)--L1/PD-,furtherunderstandingoftheregulationofPD-L1expression,therewillbeconducivetoimprovementofantiPD-L1/PD-1inthispaper,PD-.【