文档介绍：ORIGINAL ARTICLE
The Coexistence of Neuropathic Pain, Sleep,
and Psychiatric Disorders
A Novel Treatment Approach
Charles E. Argoff, MD*w
affects over 20 million individuals in the United States5
Abstract: The diagnosis and treatment of neuropathic pain may and that fibromyalgia may affect approximately 2% of
plicated orbid conditions such as sleep distur- the US population,6 the prevalence of neuropathic pain
bances, depression, and anxiety. The interrelationship between may actually be much greater than estimated.
the index neuropathic pain state and orbidities is As in other types of chronic pain, individuals with
complex: comorbid conditions exacerbate pain, and in turn, neuropathic monly orbidities, includ-
pain exacerbates orbid conditions. orbid- ing sleep disturbances and mood disorders (ie, depression
ities can negatively impact response to pain treatment, or anxiety), which pound treatment challenges of
healthcare providers should orbidities as part of the the index disease state and reduce the likelihood of a
diagnostic work-up, and management strategies should be essful clinical Because of the similarities in
designed to treat the whole patient, not just the pain. pathophysiology that underlie neuropathic pain, various
Theoretically, therapies that not only reduce pain, but also neuropathic pain syndromes respond to treatment with
improve sleep