文档介绍：生物钟PER3基因多态性与乳腺癌易感性的相关性研究
The Association between the Circadian Gene PER3 Polymorphism and the Susceptibility of Breast Cancer
曹明丽1 戴弘季2 宋丰举2 郑红2 陈可欣2*
Mingli C 1, Hongji D 2, Fengju S 2, Hong Z 2, Kexin C 2*
作者单位:
2天津医科大学附属肿瘤医院肿瘤研究所流行病室天津市300060
国家自然基金项目(编号:30771844)
The Association between the Circadian Gene PER3 Polymorphism and the Susceptibility of Breast Cancer
【Abstract】 Objective To explore the relationship between the polymorphism of the PER3 gene and the susceptibility of the breast cancer in Chinese population, Methods A case-control study was conducted, including 836 cases of breast cancer and 946 controls, PER3 gene polymorphisms were determined with polymerase chain-restriction (PCR). Results Women with a marry age more than 25 years old, a higher education level , abortion, breast benign disease, family cancer history, smoking and rich fatty intake could significantly enhance the risk of breast cancer. Late menarche, more birth and vegetable intake could significantly decrease the risk of breast cancer. And we found that the variant PER3 genotype (homozygous 5-repeat alleles) can enhance the risk of breast cancer, compared with the PER3 genotype (homozygous + heterozygous 4-repeat alleles) (OR=, 95%CI: ~, OR=, 95%CI: ~) adjusted by related factors. Conclusion The PER3 genotype (homozygous 5-repea