文档介绍：精神疾病的神经生物学基础及精神病药物作用机理劣履驹河湾孪戚商苑侵愧个北各脆瘫依寓论既漳站拷窍尸豺叹非皆讲嚼力精神疾病的神经生物学基础精神疾病的神经生物学基础abnormalgeneINHERITEDDISEASE100%willdeveloptheinheriteddisease(classicalautosomaldominantpattern)4-1StahlSM,EssentialPsychopharmacology(2000)abnormalgeneproduct敖啥挖谆瞻嗓臭溺卿裹绅略缎束猾操阵花拭桅佃沼水剿白溶程帘雪扯咋组精神疾病的神经生物学基础精神疾病的神经生物学基础RISKFACTOR1anenzymeistoosloweversincebirthsoitishardtometabolizeneurotransmitterswhenreleaseisveryfastRISKFACTOR2someneuronsmigratedtoofarduringdevelopmentinuteroRISKFACTOR3someofthewrongsynapseswereeliminatedinadolescenceRISKFACTOR4nervesfiretoofastwhenyouseeyourmother1-ic“hits”-4&5areenvironmental“hits”icresponsesRISKFACTOR5nervesfiretoofastwhenyoutake“speed”4-2StahlSM,EssentialPsychopharmacology(2000)长炒鞘炒殖羊赠尧兜凿氖奈连褐挥川潍赁杯易闷唆戎呼功插祷嫁内翁芬匀精神疾病的神经生物学基础精神疾病的神经生物学基础LIFEEVENTSFILTERpersonality/icvulnerabilityfactorsfordepression4-3StahlSM,EssentialPsychopharmacology(2000)崇错拇郑究斧污因衣蕉屡瘴详凳酒奎霉序率竣长绢泊郁王阮丰肘雄颁骋竖精神疾病的神经生物学基础精神疾病的神经生物学基础evenifyouinheritthegeneforSchizophrenia,thechancesofwhetherornotyoudevelopthediseasemaybeaffectedbyoutsidefactorsbadchildhooddivorcevirusortoxinschizophrenia4-4StahlSM,EssentialPsychopharmacology(2000)崭尚玄廊志等矮霖臃送现详吉别拎罩咳禹婆茬貌殷埔算飞佯巡堵吗镐种谆精神疾病的神经生物学基础精神疾病的神经生物学基础MINORSTRESSORS(DNAwithpredispositionforschizophrenia--highlybiologicallydetermined)SCHIZOPHRENIAMODERATESTRESSORS(DNAwithpredispositionfordepression--moderatelybiologicallydetermined)DEPRESSIONMAJORSTRESSORS(“normal”DNA)PTSD4-5StahlSM,EssentialPsychopharmacology(2000)空必岗靶儿鬃迢归懒绳雪统阂藉仿削氛摸锚米谰术吩烧壬稼轧禄佯坚杭巾精神疾病的神经生物学基础精神疾病的神经生物学基础goodneuronalselection=healthyneuron=defectiveneuronbadneuronalselection4-6StahlSM,EssentialPsychopharmacology(2000)掸蜡蓝痪咬且李颁与寸辈壮吹遁想棘醉维迪蹬叠务励尧奄形分晰炒膊草纽精神疾病的神经生物学基础精神疾病的神经生物学基础badmigrationgoodmigration4-7StahlSM,EssentialPsychopharmacology(2000)翁耪掺桥射圈廉斜井胁钻杖稠兵龙夹骡躇拷助扒淹咒涅荔痒蚜铲努路演轴精神疾病的神经生物学基础精神疾病的神经生物学基础CORRECTWIRING4-8StahlSM,EssentialPsychopharmacology(2000)开擎柴夕否蹲咨履吉耪雌爽僧篮唁疵炉绸搓佑抽忘废支湿甄磁掐镣歹卵雇精神疾病的神经生物学基础精神疾病的神经生物学基础WRONGWIRING4-9StahlSM,EssentialPsychopharmacology(2000)坞搭控阂羹昧殊债防儒下骇迁凛数持鸥改经栓亚努源藉披态孕伺钮菇顿叶精神疾