乳腺癌内分泌治疗.ppt

文档介绍：乳腺癌内分泌治疗乳腺癌的治疗方法手术化疗内分泌治疗分子靶向治疗放疗‘Subtype’SurrogateIHCmarkersTypeoftherapyNotes‘LuminalA’ERand/orPgRpositiveHER2negative,Ki-67low(<14%)herapyaloneFewrequirecytotoxics()‘LuminalB(HER2neg)’ERand/orPgRpositiveHER2negative,Ki-67highCytotoxics+herapyInclusionandtypeofcytotoxicsmaydependonperceivedriskandpatientpreference‘LuminalB(HER2pos)’ERand/orPgRpositiveHER2positiveCytotoxics+anti-HER2+herapyNodataareavailabletosupporttheomissionofcytotoxicsinthisgroup‘HER2positive(nonluminal)’Cytotoxics+anti-HER2‘Triplenegative(ductal)’CytotoxicsConsiderDNAdisruptingagents‘Specalhistologicaltypes’arcinomasmaynotrequireanyadjuvantcytotoxics.?乳腺癌Basaloid15%HER2+/ER+HER2+20-25%ER+60-70%近年来美英35-69岁乳腺癌死亡率,,(十万分之)美国7060405030201001950196019701980199020002010