文档介绍：支气管哮喘 (Asthma)哈尔滨医科大学临床第一医院呼吸内科张一梅AchronicinflammatorydisorderoftheairwaysCharacterizedby1、episodicairwaynarrowing2、increasedreactivity3、pharmacologicandspontanoudreversibilityTheclassictriadofsymptoms:1、Episodicexpiratorydyspnea2、persistentwheeze3、oughOtherassociatedsymptoms:1、chestpainortightness2、sputumproduction不可逆性狭窄气道重塑全球哮喘防治创议(GINA)GlobalInitiativeforAsthma流行病学(Epidemiology)Incidence:1-13%1—4%inChina5—10%inUSA病因和发病机制 (AetiologyandPathogenesis)icfactors:Environmentalfactors:哮喘发病机制示意图环境因素遗传易感个体炎症细胞、细胞因子及炎症介质相互作用神经调节失衡、上皮细胞及气道平滑肌结构功能异常气道炎症气道高反应性症状性哮喘环境激发因子PrecipitatingfactorsVirusAtmosdrugsOthersHousedustmiteparainfluenzaCigarettesmokingB-blockersColdairFlour,upation