文档介绍：monco-morbidities,suggestingtheconceptof“oneairway,onedisease”鼻炎=鼻部的炎症症状=流鼻涕鼻塞鼻痒打喷嚏鼻炎的病因变态反应感染性因素其他原因-药物相关的原因,PCD,囊性纤维化,免疫缺陷性因素,GORD,血管运动性,激素性,肉芽肿性过敏性鼻炎由IgE介导的鼻黏膜变应性炎症在ARIA发表之前分为-季节性过敏性鼻炎(枯草热)户外空气中的变应原引起特别是花粉常年性过敏性鼻炎由室内变应原(主要是尘螨、真菌和动物皮屑、职业性变应原)IL-10BasicproteinsEnzymesLipidmediatorsCytokinesChemokinesIL-5,IL-3GM-CSFTh0Th2EosinophilMast cellHistamineLipidmediatorsEnzymesCytokinesChemokinesIL-3IL-4Recruitment,activationAPCSelectionExpansion+AllergenCellularmechanismsofallergicrhinitisIgEAllergenNasalblockageLossofsmellNasal ‘hyperreactivity’Itch,sneezingWaterydischargeNasalcongestionSymptoms ofallergic -cell鼻炎和哮喘患者的生活质量6257Generalhealthperception5055Changeinhealth(1yr)7774Pain5559Energy/fatigue6566Mentalhealth6470Rolelimitation(emotional)6166Rolelimitation(physical)7384Socialfunctioning8980PhysicalfunctioningRhinitis(n=111)Asthma(n=252)HealthconceptMeanqualityoflifescore(scale,1-100)AmJRespirCritCareMed1994;149:373JAllergyClinImmunol1994;94:186肺鼻中耳气道平滑肌鼻旁窦鼻炎和气道高反应性