糖尿病患者结合珠蛋白基因多态性与冠脉狭窄相关性研究.doc

文档介绍：糖尿病患者结合珠蛋白基因多态性与冠脉狭窄相关性研究
潘巍巍1 王云英2 解丽艳1 王述琦1 赵琛1 范茜1 刘萍1 于楠楠1 张七一3
作者单位:1山东省青岛市市立医院干部保健科、2山东省青岛市市立医院中心实验室、3山东省青岛市市立医院心内科(266011)
通讯作者:潘巍巍 1392150333@
【摘要】目的探讨糖尿病患者结合珠蛋白基因多态性与冠状动脉狭窄严重程度的相关性。方法选择98例糖尿病合并冠心病患者以及77例单纯糖尿病患者,采用PCR-SSP技术检测结合珠蛋白基因型,据此对糖尿病合并冠心病患者进行分组,采用Gensini冠状动脉评分系统(Gensini积分)对冠状动脉的狭窄程度进行评分。结果糖尿病合并冠心病组Hp基因型分布与单纯糖尿病组相比差异有统计学意义,表现为Hp2-2基因型在糖尿病合并冠心病组的频率明显高于单纯糖尿病组( VS ,P<)。糖尿病合并冠心病组间,Hp2-2 基因型组的Gensini 积分明显高于Hp1-1/Hp1-2 基因型组(P<)。结论 Hp2-2基因型可能与糖尿病患者冠心病的发生相关,且与糖尿病患者冠脉狭窄的严重程度相关。
【关键词】糖尿病;结合珠蛋白(Hp);基因多态性;冠状动脉狭窄
Association between Haptoglobin polymorphism and coronary artery stenosis in diabetic
PAN Wei-Wei, WANG Yun-Ying, XIE Li-Yan,et al. Qingdao Municipal Hospital ,Shandong Qingdao 266011, China.
【Abstract】Objective To assess the association of Haptoglobin(Hp) polymorphism and its relationship with coronary artery stenosis in diabetic. Methods 98 diabetes mellitus (DM) with coronary heart disease(CHD) were enrolled in this study and 77 simple DM were selected as control. The PCR-SSP technology is used to explore the Hp gene and produces different teams. The Gensini score assesses the severity of coronary artery stenosis. Results The frequency of Hp2-2 genotype is significantly higher in DM with CHD group than in simple DM group( VS ,P <). And in DM with CHD group, the Gensini score of Hp2-2 genotype is higher than Hp1-1/Hp1-2 (P<).