盐酸戊乙奎醚高浓度氧雾化吸入对慢性阻塞性肺病的支气管扩张作用.doc

文档介绍：Forpersonaluseonlyinstudyandresearch;mercialuse摘要】目的评价盐酸戊乙奎醚(长托宁)对慢性阻塞性肺病(COPD)的支气管扩张作用。方法将92例COPD患者随机分为盐酸戊乙奎醚组31例,异丙托溴铵组34例,对照组27例,两个药物组吸入相应的药物,3组均吸入高浓度氧。测定所有患者用药前后第1秒用力呼气量(FEV1)变化。结果盐酸戊乙奎醚组和异丙托溴铵组FEV1较用药前均有显著增加(P<)。以FEV1改善率>15%视为有效,此两组的有效率均高于80%,二者比较无显著差异(P>)。对照组有效率低,与两个药物组比较差异显著(P<)。结论抗胆碱能药物通过降低肺动脉压力而明显改善COPD患者通气功能。【关键词】盐酸戊乙奎醚;异丙托溴铵;慢性阻塞性肺疾病;肺功能ThebronchusexpansionfunctionofpenehyclidinehydrochlorideinpatientswithCOPD YANGBo,LüXiaoHong,SHENGHui. DepartmentofPulmonaryDiseases,theFirstHospitalofJilinUniversity,Changchun130021,Jilin,China 【Abstract】ObjectiveToevaluatetheefficiencyofpenehyclidinehydrochlorideinpatientswithchronicobstructivepulmonarydisease(COPD).ytwopatientswithCOPDwererandomlydividedintothreegroup:31patientsinpenehyclidinehydrochloride,,allpatientsinthreegroupsinhaledhigh(FEV1)(P<).Theefficiencyofthetwodrugswerebothhigherthan80%,takingtheimprovementrate>15%aseffectiveness,buttherewasnosignificantdifferencebetweenboth(P>).Theefficiencyofcontrolgroupwaslower,beingdifferentfromthatofthedruggroups(P<).ConclusionsPenehyclidinehydrochloridecanobviouslyimprovethelungfunctionofpatientswithCOPDbyreduci