文档介绍：冠心病患者血尿酸水平与临床类型及院内死亡率的关系
钱赓,王峙峰,刘宏斌,陈韵岱
解放军总医院心血管内科, 北京 100853
摘要:目的探讨血尿酸(UA)水平在冠心病(CAD)不同临床类型患者中的变化,UA水平与院内死亡率和生化其它代谢指标的关系。方法收集自2009年1月-2010年1月于解放军总医院就诊的CAD患者654例的临床资料,依据临床类型分为稳定型心绞痛组(SAP)、不稳定型心绞痛组(UAP)、急性心梗组(AMI),测定血尿酸水平及其它生化代谢指标,并进行统计学分析。结果急性冠脉综合征(ACS)组:包括UAP及AMI组的血尿酸水平较SAP组有显著升高(p<),CAD患者血尿酸水平与冠心病临床类型的严重程度及院内死亡率显著相关(p<)。UA与C反应蛋白(CRP)及血肌酐(Scr)呈显著正相关((相关系数分别为r= p=;r=, P=)。结论:UA是冠心病临床病情严重程度的一个敏感指标,对于判断粥样斑块的稳定性以及心血管疾病的预后有重要价值。
关键词:冠状动脉疾病;危险因素;尿酸
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The association between serum uric acid level and severity of coronary artery disease and its relation with in-hospital death rate
Abstract:Objective To analyze the change of serum uric acid level in patients with coronary artery disease and to evaluate the relationship between uric acid level and severity of coronary artery disease. Methods We enrolled 654 eligible patients who had undergone coronary angiography between January 2009 and January 2010 ,the patients with coronary artery disease were divided into SAP group、UAP groups and AMI group. Serum uric acid were mearsured pared with the other metabolism markers. Results Acute coronary syndrome group had significantly higher level of uric acid(p<) compared with SAP group. The uric acid were significantly correlated to severity of coronary artery disease and in-hospital death rate(p<). The serum uric acid level was found