文档介绍：IMMUNOGLOBULIN
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
Emil von Behring 1854 - 1917,
Nobel Prize in 1901 for demonstrating that circulating antitoxins against diphtheria and tetanus toxins conferred immunity.
1890年德国学者Behring和日本学者北里用白喉杆菌外毒素免疫动物,在其血清中发现一种能中和这种外毒素的组分称为抗毒素。这是在血清中发现的第一种抗体。
MEDICAL IMMUNOLOGY
Gerald Edelman 1929 --
Nobel Prize in 1972
Rodney Porter 1917-1985
Nobel Prize in 1972
IMMUNOGLOBULIN
CHEN ZONGDE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY COLLEGE OF BASIC MEDICAL SCIENCE ZHENGZHOU UNIVERSITY
概念
抗体(antibody Ab ):是由 B 细胞接受抗原刺激后, 增殖分化为浆细胞后所产生的一种能与相应抗原特异性结合的球蛋白
免疫球蛋白(immunoglobulin Ig):具有抗体活性或化学结构与抗体相似的球蛋白
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
CHEN ZONGDE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY COLLEGE OF BASIC MEDICAL SCIENCE ZHENGZHOU UNIVERSITY
生物学功能上的概念
化学结构上的概念
所有的Ab都是Ig,所有的Ig并非都是Ab
免疫球蛋白的类型
分泌型免疫球蛋白(secreted immunoglobulin,sIg)
膜型免疫球蛋白(membrane immunoglobulin,mIg)
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
CHEN ZONGDE DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY COLLEGE OF BASIC MEDICAL SCIENCE ZHENGZHOU UNIVERSITY
免疫球蛋白的结构
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
免疫球蛋白的基本结构 ( 四肽链结构)
两条轻链( light chain,L链):
由 214 个氨基酸组成,分和两型
两条重链( heavy chain,H链):
由 450 ~ 550 个氨基酸组成
分为、、、、五类
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN
可变区和恒定区
可变区(variable region): VH、VL
高变区( hypervariable region,HVR )
plementarity determining region,CDR )
骨架区( framework region,FR )
恒定区(constant region): CH、CL
CH1、CH2、CH3
MEDICAL IMMUNOLOGY
IMMUNOGLOBULIN