文档介绍：DP与NP方案治疗复发转移乳腺癌临床观察
作者:陈志敏,戴秀梅,王翔,袁媛,袁保兰
【摘要】目的观察多西紫杉醇联合顺铂(DP方案)与诺维本联合顺铂(NP方案)治疗复发、转移乳腺癌的疗效及不良反应。方法 58例乳腺癌患者随机分为2组进行治疗。DP方案28例:多西紫杉醇75 mg/m2,静脉输注,第1天;顺铂25 mg/m2,静脉输注,第2、3、4天。NP方案30例:诺维本25 mg/m2,静脉输注,第1、8天; 顺铂用法同DP组。每21天为1个治疗周期。结果 DP方案总有效率(%)与NP方案总有效率(%)差异无统计学意义(P>);不良反应以胃肠道反应、骨髓抑制为主,经治疗后可耐受。结论 DP方案与NP方案对复发、转移乳腺癌均有较好疗效,蒽环类药物治疗失败的患者可选用。
【关键词】乳腺肿瘤;多西紫杉醇;顺铂;诺维本;化学疗法;转移;复发
Abstract:Objective To evaluate the efficacy and adverse reactions of docetaxel plus cisplatin (DP) and vinorelbine plus cisplatin (NP) combinations in the therapeutics of the recurrence and metastasis of breast 58 patients with breast cancer were divided into two groups at random. 28 patients in group DP received intravenous dripping of docetaxel 75 mg/m2 on the 1st day and cisplatin 25 mg/m2 on the 2nd, 3rd and 4th days. 30 patients in group NP received intravenous dripping of vinorelbine 25 mg/m2 on the 1st and 8th days and cisplatin 25 mg/m2 on the 2nd, 3rd and the 4th days. Both regimens were repeated every 3 The overall response rate for group DP was % (16/28), and in group NP, the overall response rate was % (13/30), there was no significant difference (P>). The adverse reactions, w
hich were mainly nausea /vomiting and myelosuppression, were tolerable after Both DP and bined chemotherapy produced similar effects and are