文档介绍：NFP与FP方案联合放疗治疗晚期食管癌的疗效研究
【摘要】目的通过比较NFP与FP方案联合放疗治疗晚期食管癌的疗效及不良反应,寻求食管癌更有效的治疗方法。方法 83例初治的晚期食管癌患者随机分为A、B 2组。A组(41例):FP方案(5-Fu+DDP,2~4周期)+放疗(肿瘤量60~70 Gy);B组(42例):NFP方案(NVB+5-Fu+DDP,2~4周期)+放疗(肿瘤量60~70 Gy)。结果 %,,%;%,,%,差异无统计学意义(P&gt;);主要不良反应为Ⅲ~Ⅳ度骨髓抑制,B组抑制程度高于A组(P< )。结论 NFP+放疗治疗食管癌有效率和1年生存率均不优于FP+放疗,且血液学毒性增加,尤以Ⅲ~Ⅳ度的白细胞、血小板和血红蛋白水平下降为著。
【关键词】食管肿瘤;化学治疗;放射治疗
Abstract: Objective To explore a more effective therapy for esophagus cancer paring the effects and adverse reactions of the regimens of NVB+DDP+radiotherapy (NFP+R) and 5-Fu+DDP+radiotherapy (FP+R) in the treatment of advanced esophagus cancer. Methods 83 patients with esophagus cancer for initial treatment were enrolled in the research and were randomly divided into two groups: group A (n=41) and group B (n=42). The patients in group A received the FP+R (2-4 cycles; radioactivity dose of 60-70 Gy) and the patients in group B received the NFP+R (2-4 cycles; radioactivity dose of 60-70 Gy). Results The response rate (RR), medial survival time (MST) and one-year survival rate (1 YSR) were %, months, % in group A and %, months, 1 YST % in group B, respectively. There were no statistical differences
(P&gt;) between the groups. The main adverse reaction of the two regimens was bone marrow inhibition of grade Ⅲ-Ⅳ. The inhibition degree