川芎嗪对支气管哮喘患者t.doc

文档介绍：川芎嗪对支气管哮喘患者Tbet、GATA3及气道炎症的影响
作者:殷凯生,吉宁飞,何畏,解雨春,卞涛作者单位:210029江苏省南京市,南京医科大学第一附属医院呼吸内科(殷凯生,卞涛);210024 江苏省南京市,江苏省老年医院干部保健科(吉宁飞,何畏);中心实验室(解雨春)
【摘要】目的观察川芎嗪对支气管哮喘患者气道炎症的作用以及对转录因子Tbet和GATA3表达的影响。方法 60例哮喘患者随机分成常规治疗组(A组)和川芎嗪联合治疗组(B组),每组30例。另外选取健康人30例做为正常对照组(C组)。观察治疗前后的临床疗效,采用ELISA法检测干扰素Γ(IFNΓ)和白介素4(IL4)水平,采用RTPCR法测定Tbet和GATA3的表达。结果治疗前A、B组的Tbet、IFNΓ水平明显低于C组,GATA3、IL4水平明显高于C组(P<),A、B组间没有显著差异;与治疗前比较,治疗后A、B组的Tbet、IFNΓ以及GATA3、IL4水平均有显著性差异(P<);治疗后B组的Tbet和IFNΓ水平均高于A组, GATA3和IL4水平均低于A组(P<)。结论在常规哮喘治疗的基础上,加用川芎嗪可以取得更好的疗效。川芎嗪通过纠正哮喘患者的免疫失衡来治疗哮喘,为川芎嗪对哮喘的治疗进一步提供了理论依据。
【关键词】支气管哮喘; 气道炎症; Tbet; GATA3; 川芎嗪
Effects of ligustrazine on airway inflammation and transcription factor Tbet and GATA3 expression in patients with bronchial asthma YIN Kaisheng, BIAN of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; JI Ningfei, HE Wei. Department of Cadre Health Care; XIE Yuchun. Centre Laboratory, Jiangsu Province Geriatric Hospital, Nanjing 210029,China
【Abstract】 Objective To observe the effects of ligustrazine on airway inflammation and transcription factor Tbet and GATA3 expression in elderly patients with asthma. Methods Sixty elderly patients with asthma were randomly divided into routine treatment group(group A) and ligustrazine group(group B). Thirty healthy subjects were chosen as nor