文档介绍：新生儿败血症
Neonatal septicemia
新乡医学院第一临床学院
儿科教研室
李树军
lishujun771@
QQ:524637421
新生儿感染性疾病 neonatal infectious disease
感染性疾病
新生儿病种发生改变
缺氧窒息/颅内出血
早产儿
先天性疾病
原来
目前
早产儿
感染性疾病
先天性疾病
缺氧窒息/颅内出血
common pathogen
bacteria
Neonatal septicemia
virus
TORCH infection
toxoplasma
rubella
cytomegalovirus
herpes simplex
OTHER
hepatitis B
parvovirus B19
HIV
syphilis
mycoplasma
Pathogens invade neonatal blood
circulation (bacteremia), growth,
reproduce and make toxin so that
patients appear severely infected
toxicosis symptoms. It is a total
body inflammatory reaction。
Definition
Incidence rate is high,1 ~10‰
premature higher
The third world , developing and undevelped countrys mon
Complication high : 50% complicated
acute bacterial meningitis
Mortality high,second only pneumonia
severely harm the health of neonate
Bacterial sepsis
美国与发展中国家的发病率
新生儿败血症死亡率
发展中国家
美国
Pathogenic bacteria:
Etiology
葡萄球菌
大肠杆菌
Domestic :
Invaded operation、application of broad
spectrum antibioltic 、VLBW infant survive
opportunistic pathogens(表葡、绿脓、肠杆菌、克雷伯杆菌、不动杆菌等)↑
anaerobe 厌氧菌(产气荚膜梭菌)↑
drug-resisted bacteria 耐药菌↑
new bacteria (空肠弯曲菌、幽门螺杆菌)
Overseas:
40年代-A组溶血性链球菌
50年代-金葡
60年代-大肠杆菌
At present - B组溶血性链球菌(group
us, GBS), 李斯特菌占优势;
Our country and other developing country
very low!