文档介绍：Chemical Engineering and Processing xxx (2004) xxx–xxx
Simulation and response surface analysis for the optimization
of a three-phase catalytic slurry reactor
Salah . Hasan a,∗, Delba . Melo b, Rubens M. Filho b
a School of Chemical Engineering, West of Parana State University - UNIOESTE, Rua da Faculdade, 645, CEP 85903-010, Toledo-PR, Brazil
b School of Chemical Engineering, State University of Campinas - UNICAMP, . Box 6066, 13081-970, Campinas, SP, Brazil
Received 23 May 2003; received in revised form 17 March 2004; accepted 14 May 2004
Abstract
Factorial design and response surface analysis techniques were used bination with modeling and simulation to optimize an industrial
hydrogenation process. A three-phase reactor for the production of cyclohexanol by hydrogenation of phenol in the presence of the catalyst
Ni/SiO2, with a six-stage cooling system for temperature control was considered. The model equations form a system of ordinary differential
equations derived from ic laws and steady-state balances for mass and energy for both reactants and coolant system. Initially, screening
design was used to evaluate the process variables which were relevant to the cyclohexanol yield. Two statistically significant parameters (rates
of hydrogen-QH and catalyst-QNi) were selected and used in response surface methodology for process optimization. An improv