文档介绍：School of Pharmacy
Drugs for ischemic heart
Zhu Yi Zhun, Dept. of Pharmacology, SPFDU
Email: ******@shmu.
Hypertension
• is associated with increased risk from
ischemic heart disease, cerebrovascular
accidents, heart and renal failure.
an damage
Therefore, it is important to treat hypertension and
reduce mortality and morbidity of these conditions
Complications of untreated
hypertension
• Hypertensive cardiovascular disease
• Hypertensive cerebrovascular
disease and dementia
• Hypertensive renal disease
• Aortic dissection
• plication
MYOCAIDIALMYOCAIDIAL INFARCTIONINFARCTION
Myocardial infarction ( MI ) is one of the most
common diagnoses occurring in the world. Its
mortality is approximately 30%. Although the
survival following treatment has improved in
the last two decades, the morbidity and
mortality of MI still remain high.
LEADINGLEADING CAUSESCAUSES OFOF MORTALITYMORTALITY ININ WHOWHO REPORTREPORT
The mortality of ischaemic heart disease is ranked first among
other diseases in the WHO statistics
MYOCARDIALMYOCARDIAL INFARCTIONINFARCTION
• Myocardial Infarction
generally occurs with
the abrupt decrease in
coronary blood flow
that follows a
thrombotic occlusion
of a coronary artery
leads to irreversible
myocardial cells
damage and necrosis.
Angina pectoris
• Is the mon condition involving in
tissue ischemia
• Vasodilator drugs monly used (.
nitroglycerin, calcium channel blocker)
•β-blockers are also useful
Vasodilators
• Nitrites (increase NO): venodilator (+++),
Arterioles (+), ischemic zone (+).
• Calcium channels blockers: arteriodilator (.
Nifedipine硝苯地平, verapamil异搏定, diltiazem
硫氮卓酮)
• ACE inhibitors (. Captopril开普通) and
angiotensin II receptor antagonists
(Losartan氯沙坦): mixed
Cause
• Atheromatous obstruction—most frequent
• Primary cause: imbalance between the
oxygen required by the heart and oxygen
supplied to it by the coronar