文档介绍：基因多态性的相关性
作者:杨勇舒青郑强荪李军林冯蕾
【关键词】动脉粥样硬化
关键词: 基因,DCC;串联重复序列;动脉粥样硬化;遗传易感性
摘要:目的基因STR位点多态性与动脉粥样硬化遗传易感性之间的关系. 方法利用PCR-STR方法对陕西正常老年人群(52例)动脉粥样硬化(57例)基因STR位点多态性进行群体遗传学研究,并就该位点与动脉粥样硬化关系进行关联分析. 结果基因STR位点,~,片断重复次数为37~92;DCC基因STR位点,在正常老年人群中多态信息量(PIC),杂合度(H),病例组与对照组等位基因频率分布有显著差异(χ2 =,df=13,P<),其中动脉粥样硬化组250~270bp范围内基因频率高于对照组(P<),对照组180~190bp范围内基因频率高于动脉粥样硬化组(P<);病例组与对照组杂合度与多态性分析,未见显著性差异. 结论 DCC基因STR位点多态性改变可能与动脉粥样硬化遗传易感性相关联,等位基因片断长度在250~270bp范围内的可能是动脉粥样硬化的遗传标记.
Keywords:genes,DCC;tandem repeat sequences;atherosclerosis;susceptibility
Abstract:AIM To study the relationship between ic polymorphisms of DCC gene STR in Shaanxi people and its possible association with the susceptibility of Polymorphisms of DCC gene STR was studied by PCR-STR in52unrelated individuals and57atheroscle-rosis samples in Shaanxi The frequency of alleles which were amplified in the control group was ~ the number of repetition was information content(PIC)of DCC gene STR the heterozygosity(H) distribution of allele frequency between atherosclerosis and control group was significantly different(χ2 =,df=13,P<).Compared to the amplified fragment of the control group,the frequency varying from250~270bp in atherosclerosis