文档介绍：Chinese-German Journal of Clinical Oncology January 2010, Vol. 9, No. 1, P36–P39
DOI -009-0185-5
Effects of lobaplatin and oxaliplatin on biological
behavior of colorectal carcinoma cell line
Xue Bai, Bo Yu, Junfeng Du, Shujun Yuan, Fuyi Zuo, Liang Sun
General Surgery Center of PLA, General Hospital of mand, Beijing 100700, China
Received: 17 November 2009 / Revised: 30 November 2009 / Accepted: 15 December 2009
© Springer-Verlag Berlin Heidelberg 2010
Abstract Objective: The aim of the study was to observe the effects of lobaplatin and oxaliplatin on biological behavior of
colorectal carcinoma cell line. Methods: The human colorectal carcinoma cell line LoVo and HR-8348 were used in the pres-
ent study, and different concentrations of lobaplatin and oxaliplatin served as inhibitors. The invasion and metastasis potential
were evaluated with Transwell chamber, and cell inhibition ratio was measured with MTT assay. Results: Lobaplatin and
oxaliplatin could significantly decrease the abilities of invasion and metastasis of LoVo and HR-8348 pared with the
control group (P < ), but no difference between lobaplatin and oxaliplatin groups was observed (P > ). No difference
was found in the cell inhibition ratio between the lobaplatin and oxaliplatin groups (P > ). Lobaplatin could inhibit colorectal
carcinoma cells th