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· 970 · 中华实用诊断与治疗杂志第 23 卷第 10 期
· 论著·
细胞因子诱导的杀伤细胞治疗难治性淋巴瘤的临床研究
郭智1 ,谭晓华1 ,陈丰2 ,石宇杰1 ,张明3 ,张育葵4 ,胡碧川4 ,纪妍5 ,瞿嵘5
〔摘要〕目的:探讨细胞因子诱导的杀伤细胞在难治性淋巴瘤患者中的应用及临床效果。方法:8 例难治性淋巴瘤
患者,通过血细胞分离机采集外周血单个核细胞,培养和扩增细胞因子诱导的杀伤细胞后回输至难治性淋巴瘤患者体
内,评价其疗效。结果:细胞因子诱导的杀伤细胞治疗后患者自觉症状改善,影像学复查显示 1 例多发侵犯肿块基本消
失,7 例肿块均有不同程度缩小, T 细胞亚群水平在回输后均有明显升高。结论: 细胞因子诱导的杀伤细胞治疗难治性
淋巴瘤患者可改善生活质量,不良反应小,有较好的临床效果,为难治性淋巴瘤提供了一种新的治疗方案。
〔关键词〕难治性淋巴瘤;细胞因子诱导的杀伤细胞;免疫治疗
中图分类号:R733. 4 文献标识码:A 文章编号:1674 3474 (2009) 10 0970 03
Clinical study on2 the treatment of refractory lymphoma with cytokine induced killer GUO Zhi , TAN
Xiaohua , CH EN Feng , et al. Depart ment of Hematology , General Hospital of Beijing Military Area ,
Beijing 100700 , China
〔Abstract〕Objective To discuss cytokine induced killer in refractory lymp homa patient s and t he
clinical effect . Methods Eight patient s wit h refractory lymp homa were collected peripheral blood
mononuclear cells with blood cell separator , and transfused back after t he cytokine induced killer cells
were cultured and expanded. The therapeutic effect was evaluated. Results The symptoms were
improved after treat ment by cytokine induced killer. One case of multiple violations of the t umor
disappeared , t he ot her 7 cases reduced in t umor size , and T cell subset s were obviously raised in t he
level after transfusion. Conclusion Cytokine induced