文档介绍：缺氧缺血性脑病新生儿免疫功能变化的临床意义
【摘要】目的检测缺氧缺血性脑病(HIE)新生儿血清IgG、IgA、IgM及C3、C4的变化,了解HIE对免疫功能的影响。方法 HIE患儿172例,根据年龄、病情轻重分为1~3天组84例,其中轻度HIE 36例,中重度HIE 48例;4~7天组88例,其中轻度HIE 41例,中重度HIE 47例。对照组86例为同期住院非HIE足月新生儿。检测血清IgG、IgA、IgM及C3、C4,相关结果进行统计学分析。结果 1~3天组和4~7天组轻度HIE及中重度HIE患儿血清IgM、C3、C4均低于对照组(P<),轻度HIE及中重度HIE患儿血清IgG、IgA与对照组差异均无统计学意义(P>);1~3天组和4~7天组轻度HIE及中重度HIE患儿间血清IgG、IgA、IgM、C3、C4差异均无统计学意义(P>)。结论 HIE可使患儿IgM及补体水平降低,但与HIE的程度无关。
【关键词】缺氧缺血性脑病;新生儿;免疫功能
Abstract:Objective To investigate the changes of serum IgG, IgA, IgM, C3 and C4 in neonates with hypoxic-ischemic encephalopathy (HIE).Methods 172 neonates with HIE and 86 non-HIE normal full-term infants were recruited in the study. The HIE neonates were divided into a 1-3 day group (n=84) and a 4-6 day group (n=88), which were further divided into mild and moderate-severe subgroups. The Igs plements in serum were determined by radial immunodiffusion The levels of IgM, C3 and C4 were lower in both 1-3 day and 4-6 day groups th
an in the control (P<). But the levels of IgG and IgA did not show such differences significantly (P>). No significant differences in the results were found between the two age groups of the babies, or the varied severities of HIE, in the varied Igs plements (P>).Conclusion The levels of IgM, C3 and C4 are lowered in HIE neonstes, but the severity of HIE does not contribute