文档介绍：中文摘要关键词:脑缺血;再灌注损损伤;缺血后处理;线栓法第一部分缺血后处理发挥脑保护作用的最佳方案目的:建立大鼠局灶性脑缺血后处理,P停教諭对局灶性脑缺血再灌注痳,疪鹕朔⒒幽员;ぷ饔玫淖罴逊案。方法:成年健康雄性狣笫唬婊治组:假手术组组、缺血再灌注/组、、一癐亲椋孔榇笫蟾只。局灶性脑缺血再灌注模型采用线栓法阻塞大脑中动脉琈,拔出线栓恢复再灌注琁髯榉椒ㄎT贛后持续再灌注前,分别给予鲅返////俟嘧ⅲ血。各组大鼠于再灌注猩窬δ芷婪郑⒉舛ㄏ赴蛲黾澳怨K捞寤范发挥脑保护作用的最佳方案。结果:成功建立线栓法缺血再灌注P汀/榇笫罂杉窬δ苋笔А缺血侧大脑半球梗死及凋亡细胞大量表达。与疪组相比,、、一榻螴/槟怨K捞寤暗蛲鱿赴计数显著显著降低,:改良线栓法制备脑缺血耐受模型切实可行;可减轻脑缺血再灌注损伤,发挥脑保护作用;作用效果有时间窗限制,最佳方式为再灌注毖,反复巍、
因子第二部分缺血后处理对脑缺血再灌注大鼠硕士研究生吕敬雷窬⊙指导教师赵仁亮教授关键词:脑缺血;缺血后处理;再灌注损伤;白细胞介素恢琢龌邓【表达的影响目的:探讨对局灶性脑缺血再灌注大鼠白细胞介素和肿瘤坏死因子一—琓泶锏挠跋欤佣明的脑保护作用机制。方法:将成年健康雄性大鼠凰婊治<偈质⑷毖T俟嘧/组和组,根据再灌注时间后两组又分为、、甯鲅亲椤2捎么竽灾卸鱿咚ǚń⒕衷钚阅匀毖T俟嘧⒛P停琁椒ㄎT大脑中动脉阻闭后实施再灌注毖,反复巍6愿髯榻猩窬δ苎评分,旧ú舛怨K捞寤庖咦榛ḿ觳饽宰橹疘达,原位杂交法检测的表达。结果:榧浔冉希篢/榇笫罂杉窬δ苋笔Ъ叭毖2啻竽园肭蚬K溃河隝/橄比,组大鼠神经行为学评分改善,/镮蛋白及表达开始升高,锏礁峰,后逐渐下降,。结论:显著下调蚑—泶铮跣/笫竽怨K捞寤崾綢擅飨抑制脑组织疪后的炎性反应,从而发挥神经保护作用。和鞍椎谋蚑琁
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目录第一章缺血后处理发挥脑保护作用的最佳方案第二章缺血后处理对脑缺血再灌注大鼠和泶锏挠跋中文摘要······························································英文摘要······························································前言···································································材料和方法·····························································结果··································································讨论·······&#