文档介绍：MECHANISMSOFSELF-DEFENSE–,PhD,RNINNATEDEFENSESBody’s1stlineofdefense:anatomicbarriersTheskin&rated:Mechanicalclearance2ndlineofdefense:InflammatoryresponseIMMUNERESPONSE3rdLineofdefense:ImmuneResponseSlower&paredtoinflammatoryresponseInflammatory&plementeachother&plexsystemElaborate&workRecognizes&respondstoantigensCells&moleculesoftheimmunesystemprotectthenosefromattackbyavirusCHARACTERISTICS OFIMMUNERESPONSEImmunityStateofprotection,primarilyagainstinfectionsCharacterizedbymemory&ponentsoftheimmuneresponseImmunogensAntigensthatinduceanimmuneresponseHaptensAntigensmustbeboundtocarrierstoinduceanimmuneresponseSelf-AntigensAntigensonhostcellsNotrecognizedasimmunogenicbyhost’simmunesystemAconditioncalledtoleranceCHARACTERISTICS OFIMMUNERESPONSEINDUCTIONOFIMMUNERESPONSEMostimmunesystemcellsareWBCsImmunocytes(lymphocytes)are1typeofWBC2majorclassesofimmunocytesTlymphocytes(Tcells)&Blymphocytes(Bcells)ImmuneresponseischaracterizedbytheactivationofBcells&TcellsBCELLSDevelopsfromastemcellthatmaturesunderhormonalcontrolinbursal-equivalenttissues(bonemarrow)DevelopsintoamatureplasmacellcapableofproducingantibodyagainstaspecificantigenAntibodymarkstheantigenfordestructionbyotherimmunecellsANTIBODIESPlasmaglycoproteinsClassifiedbychemicalstructure&biologicactivityIgG,IgM,IgA,IgE,orIgDProtecthostfromharmfulantigensRecognizeandbindwithantigensFunctions:Opsonizebacteria,neutralizetoxins&virusesActivatesinflammatoryresponse