文档介绍：2型糖尿病患者粘附分子与颈动脉粥样硬化相关性研究
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【摘要】目的讨论粘附分子对2型糖尿病患者颈动脉粥样硬化的影响。方法收集85例已确诊的2型糖尿病患者,以彩色多普勒超声诊断仪检测患者双侧颈动脉壁厚度以及动脉粥样硬化程度。据颈动脉超声结果将患者分为四组即颈动脉正常组、颈动脉内膜增厚组、稳定斑块组、不稳定斑块组。检测血清胰岛素、胰岛素原、血管细胞间粘附分子-1、糖化血红蛋白、血脂系列、C反应蛋白及尿微量白蛋白。分析这些因素与颈动脉粥样硬化之间的关系。结果 4组间胰岛素、胰岛素原、糖化血红蛋白、体重指数、C反应蛋白、尿微量白蛋白均无明显差异;而颈动脉内膜增厚组、稳定斑块组、不稳定斑块组的年龄、甘油三酯、总胆固醇低密度脂蛋白、高密度脂蛋白及血管细胞间粘附分子-1明显高于颈动脉正常组。多元逐步回归分析结果显示患者的年龄、甘油三酯、低密度脂蛋白、血管细胞间粘附分子-1与颈动脉粥样硬化有相关性。结论血管细胞间粘附分子-1浓度可能为糖尿病大血管病变的血清学标志物之一。
【关键词】糖尿病;颈动脉粥样硬化;血管细胞间粘附分子-1
[Abstract] Objective To discuss the influence of adhesion molecule on type 2 diabetes. Methods 85 cases of type 2 diabetes were selected and examined their arterial wall thickness and local atherosclerosis in the carotid arteries (CAs) by B-mode ultrasonography of CAs. According to the results of B-mode ultrasonography, 110 cases were disparted for four groups: carotid arteries normal, carotid arteries incrassation, stabilization plaque and unstabilization plaque. Limosis serum insulin, proinsulin, sVCAM-1, HbA1c, CHO, TG, LDL-C, HDL-C, CRP and microalbuminuria were determined. The relationships between these factors and the grades of carotid arteries arteriosclerosis were analyzed. Results There was no significant difference in insulin, proinsulin, HbA1C, BMI, CRP and microalbuminuria among four groups. The level of CHO, TG, LDL-C, HDL-C and sVCAM-1 were lower in normal gro