文档介绍：10例儿童狼疮性肾炎病理与临床分析
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【摘要】目的分析肾活检病理与实验室指标,探讨儿童狼疮性肾炎(Lupus Nephritis,LN)病理与临床的关系。方法根据WHO1982年的分型标准对10例儿童LN病例分型,对各型LN病例的肾活检病理及实验室指标等结果进行比较。结果病理类型以IV型LN最多,临床表现以肾病综合征型为主,IV型LN肾组织受损最为严重。结论儿童LN的病理与临床之间存在一定关系,积极肾活检对治疗及预后有重大价值。
【关键词】儿童狼疮性肾炎病理类型
【Abstract】 Objective To explore the relationship between the pathological classification and clinical manifestations of Lupus Nephritis (LN) in children by renal biopsy and laboratory examination. Method The pathological classification of LN was made according to the criteria of WHO 1982, pare the Renal biopsy and routine laboratory in different types of LN. Results Type IV of LN was the mon,and usually appeared as nephritic renal injury of type IV of LN was relatively obvious. Conclusion A positive correlation is demonstrated between pathological classification and clinical manifestation of LN in children. Renal biopsy was valuable for treatment and prognosis evaluation of LN.
【Key Words】 Children Lupus nephritis Pathological type
系统性红斑狼疮(Systemic Lupus Erythematosus,SLE)是一种自身免疫性疾病,几乎所有的SLE患儿均出现肾脏受累,表现为狼疮性肾炎(Lupus Nephritis,LN)。LN不仅是儿童SLE最常见和最严重的危及生命的主要原因之一,也是影响远期预后的关键。肾组织病理活检是LN诊断和治疗的重要手段。本文通过对福建省立医院近年来10例LN病例的回顾性分析,结合查阅文献资料,探讨LN病理与临床表现、实验室检查及肾损害程度之间的关系。
1 资料与方法
资料福建省立医院2005-2011年住院治疗的LN患儿10例,其中女性9例,最小年龄9岁,最大年龄13岁,平均年龄10岁;男性1例,年龄14岁,男女比例为1:9。发病时间距离首次就诊时间最短7天,最长10个月,平均