Caspase-9和Bax在胃癌组织中的表达及其意义.doc

文档介绍：Caspase-9和Bax在胃癌组织中的表达及其意义
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【摘要】目的:探讨凋亡基因Caspase-9和Bax在胃癌中的表达与意义。方法:应用免疫组化S-P法检测Caspase-9和Bax在57例胃癌及48例非癌胃黏膜组织中的表达。结果:Caspase- %, %,两组比较差异有统计学意义(); %, %,两组比较差异有统计学意义();高中分化腺癌组Caspase-9和Bax蛋白的阳性表达率明显高于低分化腺癌组及粘液癌组,两者间差异有统计学意义();Bax和Caspase-9蛋白在胃癌组织中的表达与淋巴结转移、浸润深度、临床病理分期均无明显关系();在胃癌组织Caspase-9表达阳性的23例中有Bax表达阳性17例,在胃癌组织Bax表达阴性37例中Caspase-9表达阴性31例,两者比较差异有统计学意义()。结论:Caspase-9和Bax在胃癌组织中表达降低,提示二者可能与胃癌的发生或发展相关;随着胃癌分化程度的降低,Caspase-9和Bax的表达降低,提示二者可能与胃癌的恶性程度有关;胃癌组织中Caspase-9和Bax表达有关,推测Bax激活Caspase-9的线粒体通道受抑可能参与胃癌的发生。
【关键词】 Caspase-9;Bax;胃癌;免疫组织化学
Abstract Objective: To explore the expression of Caspase-9 and Bax in gastric carcinoma and their significance. Methods: Immunohistochemistry SP was used to detect the expression of Caspase-9 and Bax in 57 patients with gastric carcinoma and 48 patients without gastric carcinoma. Results: The positive expression of Caspase-9 protein in gastric carcinoma was %, which was significantly lower than that ( %) in those without gastric carcinoma (). The positive expression of Bax protein in gastric carcinoma was %, significantly lower than that ( %) in those without gastric carcinoma (). The positive expression of Caspase-9 and Bax protein in well and moderately differen