文档介绍：CD99蛋白在胃腺癌组织中的表达及其临床意义
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作者: 玄延花,刘双平,任香善[摘要] [目的] 探讨CD99蛋白表达在胃腺癌诊断中的意义. [方法] 采用免疫组织化学方法给111例胃腺癌和20例正常胃黏膜组织进行CD99蛋白表达检测. [结果] CD99蛋白在正常胃黏膜细胞膜上呈高度表达,在胃腺癌细胞中呈低度表达,±,±,,且进展期Ⅰ期病变中的积分数高于进展期Ⅳ期. [结论] CD99蛋白的免疫组织化学检测可作为胃腺癌早期诊断的参考指标.
[关键词] 胃肿瘤;CD99;免疫组织化学
(Department of Pathology and Forensic Medicine,Yanbian University College of Basic Medicine,Yanji133000,Jilin,China) ABSTRACT:OBJECTIVE To evaluate the pathologic significance of the expression of CD99in gastric The immunostaining was done using a CD99antibody in111of gastric adenocarcinomas and20of normal gastric The expression of CD99was very rare in gastric adenocarcinoma
,only several cases of gastric cancer cells showed weak positive signals,but its expression was frequently observed in normal gastric immunoreactive score of ±±, expression of CD99was significantly higher in early gastric cancer and stageⅠtissues than advanced gastric cancer and stageⅣ.CONCLUSION The expression of CD99was a useful marker for the diagnosis of gastric adenocarcinoma.
Key words:stomach neoplasms;CD99;immunohistochemistry
CD99蛋白是由mic2基因编码的广泛存在于各种细胞内的跨膜蛋白,、原发性神经外胚瘤、淋巴母细胞瘤、横纹肌肉瘤和软骨肉瘤等间叶组织肿瘤的诊断中有重要意义[1~3] .本研究