文档介绍：FHIT抑癌基因在乳腺癌组织中的表达缺失
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作者:金春亭李海军张林西李玉珍范婕武欣白美玲
【摘要】目的:探讨FHIT基因蛋白在乳腺癌中的表达特点及其与临床病理参数的关系。方法:采用免疫组织化学SP法,检测62例乳腺癌组织中FHIT蛋白的表达情况。结果:%,%。FHIT蛋白在导管内癌局部浸润组的阴性表达率为30%,明显低于浸润性导管癌组(%),但是没有统计学差异;临床Ⅰ~Ⅱ%,明显低于Ⅲ~Ⅳ期阴性表达率(%)(P=)。%,显著高于无淋巴结转移组(%)(P=)。FHIT蛋白的表达缺失与患者年龄、癌的左右乳分布没有显著性差异。结论:乳腺癌组织中有FHIT蛋白的表达缺失,可能参与或促进乳腺癌的形成。
【关键词】 FHIT;乳腺癌;免疫组织化学
【ABSTRACT】 Objective: To investigate the expression characteristics of FHIT protein in breast carcinomas and its relationship with clinicopathological parameters. Methods: Expression of FHIT protein in breast carcinoma tissues of 62 cases was detected by SP immunohistochemistry. Results: The positive rate of FHIT protein expression in breast carcinoma tissues was %, and about % cases lost FHIT expression. Negative rate of FHIT expression in early invasive ductal carcinoma in situ group was obviously lower than that i
n invasive ductal carcinomas group (%), but the difference wasnt significant. Also, loss of FHIT expression in stage Ⅲ~Ⅳ was higher than that in stage Ⅰ~Ⅱ(P=). There was % breast carcinomas with lymph node metastasis lossing FHIT expression, the lossing rate was significantly higher than that in carcinomas without metastasis (P=). FHIT expression had no relationship wit