HLADQA1等位基因与新疆哈萨克族原发性高血压的相关性.doc

文档介绍：HLADQA1等位基因与新疆哈萨克族原发性高血压的相关性
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作者:王红英,邢建新,周康,潘泽民,陆林,马海梅,张慧,张妍
【摘要】目的探讨新疆哈萨克族原发性高血压与HLADQA1等位基因的相关性。方法应用病例对照相关性分析方法及PCRSSP基因分型技术对新疆哈萨克族健康个体83例和高血压病患者80例(均无血缘关系),进行了HLADQA1等位基因分型。结果原发性高血压患者中DQA1*%,显著高于对照组(%),χ2=,,OR=。DQA1*0103的频率(%)显著低于对照组(%),χ2=,。OR=。结论 HLADQA1*0301可能与新疆哈萨克族原发性高血压易感相关,而HLADQA1*0103可能在新疆哈萨克族原发性高血压发病中有保护作用。
【关键词】高血压病;HLADQA1;等位基因;新疆哈萨克族
ABSTRACT: Objective To investigate the relationship between the alleles of human leukocyte antigens (HLA) DQA1 and essential hypertension (EH) in Xinjiang Kazak population in China. Methods Alleles of HLA
DQA1 were typed by polymerase chain reactionsequence specific primers techniques in samples of 80 EH patients and 83 healthy people in casecontrol study (EH patients and healthy people as controls had no consanguinity with each other). Results The frequency of DQA1*0301 was %, significantly higher in the EH patients than in the controls (%) (χ2=, ). Odds ratio (OR) was frequency of DQA1*0103 significantly decreased in the group of patients with EH parison to the controls (% vs. %) (χ2=, ). OR was . Conclusion HLADQA1*0301 was related to the susceptibility of essential hypertension in the Xinjiang Kazak population in China. In addition, it is possibl