文档介绍：MTA1蛋白表达与口腔鳞癌临床病理特征的关系
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作者:王永霞,陈桂林,李伟宏
【摘要】目的:探讨MTA1蛋白在口腔鳞癌中的表达及其与口腔鳞癌临床病理特征的关系。方法:采用免疫组织化学法检测54例口腔鳞癌标本与20例正常口腔黏膜标本中MTA1蛋白的表达,并分析MTA1蛋白表达与口腔鳞癌患者临床病理特征的关系,包括患者年龄、性别、癌组织分化程度、浸润深度、临床分期及有无淋巴结转移。结果:MTA1蛋白主要表达于细胞核或细胞浆,%(39/54),而正常口腔黏膜组织中未见表达或仅有微弱表达(%),二者差异有统计学意义();MTA1蛋白高表达与癌组织分化程度、肿瘤浸润深度、临床分期及淋巴结转移密切相关,而与患者的年龄、性别无明显关系。结论:MTA1蛋白高表达在口腔鳞癌的发生、发展及浸润转移过程中可能起一定作用;MTA1蛋白有望成为判断口腔鳞癌患者预后及选择治疗方案的一个新肿瘤标志物。
【关键词】 MTA1蛋白;口腔鳞癌;免疫组化;高表达;浸润转移

[ABSTRACT] Objective: To study the expression of metastasisassociated gene1 (MTA1) in tumorigenesis and progression of oral squamous cell carcinoma (). Methods: MTA1 protein expression and its relation to clinicopathological features of were examined in 20 normal oral tissues and 54 by immunohistochemical SP methods. Results: The overexpression rate of MTA1 in was %(39/54), which was significant higher than that of the control group 25%(5/15) (). The overexpression of MTA1 among the lower differentiated tissues were significant higher than the higher differentiated tissues of () , and the findings among the groups of intramuscular infiltration were similar higher than the group of nonintramuscular infiltration, the Ⅲ, Ⅳ clinical stages higher than Ⅰ,Ⅱ clinical stages, and lymph node involvement higher than the nonlymph node involvement of (). Conclusions: The overexpression of MTA1 might play an important role in the pathogenesis and development of , and it might be a target for the therapy and prognostic indicator of .

[KEY WORDS] MTA1 protein; Oral squamous cell carcinoma; Immunohistochemical; Overexpression; Clinicopathological features
口腔鳞癌(oral squamous cell carcinaoma, )是头颈部最常见的恶性肿瘤之一,近年来发病率呈上升趋势,已证实其发生发展与多个基因的异常表达有关。肿瘤转移相关基因1(metastasisassociated gene 1, MTA1)是近年来新发现的一个与多种肿瘤浸润转移密切相关的基因, 研究表明其编码的MTA1蛋白在乳腺癌、肺癌、喉癌及卵巢癌[14]等多种恶性肿瘤中高表达,且参与了肿瘤的浸润与转移。本研究采用免疫组织化学染色法检测MTA1蛋白在口腔鳞癌及正常口腔黏膜组织标本中的表达情况,探讨其在口腔鳞癌发生发展中的作用。
1 材料与方法
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